Kalıypa SALİYEVA | Bakıt BORKOYEV

Review | 2024 | Polymer Bulletin ( Published online: 27 March 2024 )

Molecularly imprinted polymers (MIPs) are handmade receptors that mimic the binding of natural antibodies. In other words, MIPs can selectively bind to the target molecule and qualify as bio-inspired synthetic materials. Today, MIPs are used extensively and are being developed further for biological applications. High cost and time consuming techniques are compelling factors for the field of biochemistry, biomedicine and biotechnology (3B), and there is an urgent need for an alternative, cheap, easy to produce, fast and effective method in these fields. MIPs stand out as a promising way for this purpose. MIPs have superiorities such . . . as specific recognition specificity, excellent sensitivity selectivity and reusability. From this point of view, we examined MIP-related drug delivery studies, cell recognition, enzyme applications, in vivo applications, and applications for some important biomolecules. The aim of this review is to compile the utilizations, advantages, important developments and future expectations of MIPs for the fields of 3B. Keyword: biochemistry; biomedical; biotechnology; molecular ımprinted polymer More less

Nahit AKTAŞ

Article | 2021 | Polymer Bulletin79 ( 10 )

To reduce water pollution caused by fertilizers in agricultural irrigation, highly swelling crosslinked hydrogels (p(DMAAm-co-MA) or DM1) based on N,N-dimethylacrylamide (DMAAm) and maleic acid (MA) were prepared using a chemical initiator with the redox polymerization technique. Negative and positive surface modifications of DM1 were achieved using hydrochloric acid (HCl) (p(DMAAm-co-MA)/HCl or DM2) and sodium hydroxide (NaOH) (p(DMAAm-co-MA)/NaOH or DM3), respectively. The synthesized hydrogels were named DM1, DM2 and DM3, respectively. The swelling properties, urea sorption and urea release kinetics of synthesized hydrogels were . . .analyzed in deionized water at different pHs. The sorption isotherms and sorption parameters were investigated thoroughly for all hydrogels and the Langmuir (L) isotherm showed the best fit. In order to examine the urea release mechanism from all hydrogels, four mathematical models of zero-order kinetic model (Z-O), first-order kinetic model (F-O), Higuchi (H) and the Korsmeyer-Peppas power law (K-P) were studied to fit the experimental data. The hydrogels exhibited swelling and releasing properties that were highly dependent on their functional groups and the ionic forces in the medium. Cumulative urea release values for DM1, DM2 and DM3 were calculated as 100?t pH 10, 100?t pH 8 and 100?t pH 8 within 48, 41 and 18 h, respectively. It was confirmed by experimental studies that the prepared hydrogels and their derivatives can be used as carriers for fertilizers, particularly urea, as well as controlled water release sources. As a result, the use of the synthesized hydrogels to prevent contamination of water resources with agricultural products and to provide a nitrogen source that plants require comprise the innovative and original aspect of the article More less

Nahit AKTAŞ

Article | 2023 | Polymer Bulletin ( Published online: 31 July 2023 )

Interest in synthesizing functional materials from natural compounds has increased recently. For this reason, compound particles attract attention due to their multifunctional properties. Abelmoschus esculentus L. (Okra) is a vegetable species belonging to the Hibiscus family, widely used for its edible unripe fruit. This study synthesized the particle from the Abelmoschus esculentus (Okra) extract (Oe) by emulsion polymerization. In this synthesis, ammonium persulfate (APS, initiator) to form free radicals at the Abelmoschus esculentus (Okra) extract (Oe) and ethylene glycol di methacrylate to cross-link the formed radicals were us . . .ed. The synthesized poly(Okra) ((p(O)) particles structure Field emission scanning and Fourier transform infrared and biological activities (biocompatible, antioxidant, antimicrobial, and hydrogen peroxide scavenging) were characterized. The p(O) particle showed good antimicrobial activity against Staphylococcus aureus, Bacillus cereus, Enterococcus faecalis, and Candida albicans. It has been measured to have high antioxidant and hydrogen peroxide scavenging activity with p(O) particles. Keyword: okra extract; particle; antioxidant; H2O2 scavenging; biocompatibl More less

Nahit AKTAŞ

Article | 2021 | Polymer Bulletin79 ( 8 )

The aim of this study was to synthesize organo-hydrogels, by using agar, glycerol and different amounts of castor oil in one step, with biocompatible, blood-compatible and antioxidant properties using a new approach to the synthesis of smart polymers. Then, the target was to investigate the applicability of these organo-hydrogels as a drug release system. In the synthesis of organo-hydrogels, crosslinking was achieved with MBA or GA reagent and the redox polymerization technique was applied in the emulsion medium. The swelling behaviors of organo-hydrogels, which were synthesized using different crosslinkers and varying amounts of c . . .astor oil, were investigated in different solvent systems (ethanol, acetone, ethanol/DI water (1:1), acetone/DI water (1:1) and gasoline) and in different pH (2.0-12) media. In addition, FTIR, antioxidant, blood clotting and hemolysis analyses were evaluated in light of the results obtained. In the last stage of the study, drug-loaded organo-hydrogels were synthesized by the direct drug loading method and used as a drug delivery vehicle. Vitamin D-3, which is of great importance in the human body and used as an antibiotic, was selected as a model drug. Release studies were carried out in different pH media because various areas of the human body were the main targets in this study and the plan was to provide controlled release of the drug substance in these regions. The pH values of these regions were important in terms of application. Therefore, pH (2.0-12) values for various parts of the human body were imitated in the laboratory environment and release behaviors were examined in experimental studies. It can be said that the synthesized organo-hydrogels were suitable for use as drug transport systems in light of the obtained results More less

Nahit AKTAŞ

Article | 2020 | Polymer Bulletin78 ( 11 )

Novel biocompatible homo and co-polymeric microparticles were synthesized from maleic acid (MA) and citric acid (CA) for uptake/release thiamine as a model drug. Surfactant-free self-emulsion polymerization technique was accomplished to synthesize the microparticles in a single step. The antimicrobial, antioxidant properties of those microparticles and their thiamine uptake/release capacities were investigated. Fourier transform infrared spectroscopy (FTIR), thermogravimetric analyzer (TGA), particle-size/zeta-potential (Zeta/DLS) and scanning electron microscopy (SEM) instruments were utilized for the characterizations of micropart . . .icles. FTIR revealed the existence of bonding interaction between the carboxylic acid groups of CA and MA. TGA results represented that thermal decomposition of microparticles was gradually continuing up to 1000 degrees C. The hydrodynamic diameters of poly (CA), poly (MA), poly (CA-co-MA) microparticles were found to be in the range of 681 nm, 1273 nm, 1604 nm, respectively. The zeta potential of those microparticles was in the range of - 5.69 mV, - 16.90 mV and - 7.73 mV, respectively. The studies demonstrated that all microparticles have superior properties to absorb and release thiamine compared with similar candidates. Furthermore, controlled release behavior of thiamine was examined using zero sequence, first-order, Higuchi and Korsmeyer-Peppas models in PBS solutions at pH 7.4. Thiamine release from all microparticles exhibits a very high correlation with the Korsmeyer-Peppas semiempirical model and could be interpreted by the superposition of both Fickian diffusion and non-Fickian diffusion based on Peppa More less

Bakıt BORKOYEV | Kalıypa SALİYEVA

Article | 2023 | Polymer Bulletin ( Published online: 21 November 2023 )

The present study draws attention to arsenic (V) (As(V)), chromium (III) (Cr(III)), and chromium (VI) (Cr(VI)) heavy metal pollutants, which have negative effects on aquatic ecosystems and indirectly pose a serious threat to the health of living things in the environment. Homopolymer and copolymer hydrogels were synthesized by the UV polymerization technique using 2-acrylamido-2-methyl-1-propansulfonic acid sodium salt (AMPS) and 3-acrlylamidopropil-trimethyl ammonium chloride monomers, and a crosslinker aimed to improve the swelling properties and metal sorption of the prepared hydrogels. The swelling balance values of hydrogels we . . .re determined by the gravimetric method in deionized water and different pH values, and their structural characterizations were carried out by Fourier transform infrared spectroscopy (FT-IR) and thermal gravimetric analysis (TGA) techniques. Sorption efficiencies and sorption capacities of the synthesized hydrogels were determined using aqueous solutions containing As(V), Cr(III), and Cr(VI) heavy metal ions at 25 °C. It was determined that there was a significant increase in p(AMPS) (AM1)-based hydrogel's balance swelling value in deionized water compared to p(AP1) and p(AMPS-co-APTMACl) (AMAP1)-based hydrogels. The lowest equilibrium swelling value was reached in the AMAP1 hydrogel, and the main reason for this result was thought to be due to the closure of the active functional groups of the increased cross-links between AMPS and APTMACl monomer. When sorption results were examined, it was observed that the highest heavy metal ion removal for AM1, AP1, and AMAP1 was in As(V) metal. The highest metal ion holding capacity of AM1, AP1, and AMAP1 was found to be 494 mg/g, 2336 mg/g, and 1439 mg/g for As(V), 323 mg/g, 111 mg/g, and 276 mg/g for Cr(III), and 303 mg/g, 723 mg/g, and 554 mg/g for Cr(VI), respectively. Considering the swelling and sorption results, it is thought that the synthesized hydrogels will provide a significant advantage in the removal of heavy metal ions, which have negative effects on environmental pollution and live health. Keyword: copolymeric hydrogel; heavy metal; homopolymeric; sorption kinetics; sorption mechanis More less